Reaktion #2086

Reaktionsgleichung

1-benzyl-3-methylxanthine hydrochloride

diethyl 4-chlorobutanephosphonate

potassium carbonate

→

Diethyl [4-(1-benzyl-3-methylxanthin-7-yl)butyl]phosphonate

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solution was filtered hot
2. 2
   Sonstigethe dimethylformamide was evaporated under reduced pressure
3. 3
   Waschenwashed several times with water
4. 4
   SonstigeAfter evaporating the solvent, it
5. 5
   Sonstigewithout purification

Vorschrift

20 g (0.078 mol) of 1-benzyl-3-methylxanthine hydrochloride, 21.4 g (0.094 mol) of diethyl 4-chlorobutanephosphonate and 26 g (0.2 mol) of potassium carbonate were suspended in 400 ml of dimethylformamide and stirred at 70° C. for 6 hours. The solution was filtered hot and the dimethylformamide was evaporated under reduced pressure. The oily residue which remained was taken up in dichloromethane and washed several times with water. After evaporating the solvent, it was possible to reuse the pale yellow, oily residue without purification.

Quelle