Reaktion #2084

Reaktionsgleichung

benzyl bromide

7-ethoxymethyl-3-methylxanthine

potassium carbonate

→

1-Benzyl-7-ethoxymethyl-3-methylxanthine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction solution was filtered hot
2. 2
   Einengenthe filtrate was concentrated under reduced pressure
3. 3
   Sonstigethe residue was dried to constant weight in a bulb tube at 1 mbar and 60° C.

Vorschrift

205 g (1.2 mol) of benzyl bromide were added to a suspension of 224 g (1 mol) of 7-ethoxymethyl-3-methylxanthine and 165 g of potassium carbonate in 1000 ml of dimethylformamide and the mixture was then stirred overnight at 90° C. The reaction solution was filtered hot, the filtrate was concentrated under reduced pressure and the residue was dried to constant weight in a bulb tube at 1 mbar and 60° C.

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