Reaktion #2083089

ord-4a17418d67f54ed58e14214076602ac4

Reaktionsgleichung

CC1(C)CC1C(=O)N/C(=C\CCCCBr)C(=O)O
(+) Z-7-bromo-2-(2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid
O=C(O)c1cccnc1S
2-mercaptonicotinic acid
O=C([O-])[O-].[Na+].[Na+]
Na2CO3
→
CC1(C)CC1C(=O)N/C(=C\CCCCSc1ncccc1C(=O)O)C(=O)O
(+)-Z-7-(3-carboxy-2-pyridylthio)-2-(2,2-dimethyl cyclopropanecarboxamido)-2-heptenoic acid

Edukte

CC1(C)CC1C(=O)N/C(=C\CCCCBr)C(=O)O
(+) Z-7-bromo-2-(2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid
O=C(O)c1cccnc1S
2-mercaptonicotinic acid
O=C([O-])[O-].[Na+].[Na+]
Na2CO3

Reagenzien

Keine

Lösungsmittel

O
H2O

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

A solution of 600.0 mg (1.89 mmole) of (+) Z-7-bromo-2-(2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid, 267.0 mg (1.72 mmole) of 2-mercaptonicotinic acid and 400.6 mg (3.78 mmole) of Na2CO3 in 3.0 ml of H2O was stirred under N2 at room temperature.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04406902uspto-grants-1983_09