Reaktion #2082781

Reaktionsgleichung

2-cyanoacetamide

2-(4-chlorophenyl)-3-(dimethylamino)acrolein

→

5-(4-CHLOROPHENYL)-3-CYANO-2-(1H)-PYRIDONE

Lösungsmittel

Sodium

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   TemperaturThe mixture was refluxed for 1 hour
3. 3
   Filtrationthe resulting precipitate was filtered
4. 4
   Waschenwashed with ethanol
5. 5
   workup.DISSOLUTIONdissolved in hot water
6. 6
   FiltrationThe resulting precipitate was filtered
7. 7
   Waschenwashed with water

Vorschrift

Sodium (7 grams in 300 ml methanol) was stirred while a methanolic solution of 2-cyanoacetamide (16 grams) and 2-(4-chlorophenyl)-3-(dimethylamino)acrolein (37 grams) was added. The mixture was refluxed for 1 hour and the resulting precipitate was filtered, washed with ethanol, dissolved in hot water, and then acidified. The resulting precipitate was filtered, washed with water, and identified as the desired product, m.p. 278°-280° C.

Quelle