Reaktion #2082495

Reaktionsgleichung

ethyl 4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine-3-carboxylate

ammonium hydroxide

→

3-carbamoyl-4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine

Ausbeute 97.5%

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitated crystals are filtered
2. 2
   Waschenwashed with water

Vorschrift

11.8 g. of ethyl 4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine-3-carboxylate are dissolved in 40 ml. of 30% by wieght ammonium hydroxide solution and the reaction mixture is allowed to stand at room temperature for 2 hours. The precipitated crystals are filtered and washed with water. 10.1 g. (97.5%) of 3-carbamoyl-4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine are obtained melting at 234°-235° C.

Quelle