Reaktion #2080086

Reaktionsgleichung

2-Bromo-6-(methyloxy)-3-(3,3,3-trifluoropropyl)-1-naphthalenol

chloromethyl methyl ether

diisopropylethylamine

→

title compound ( 123 )

Ausbeute 80.0%

2-Bromo-6-(methyloxy)-1-{[(methyloxy)methyl]oxy}-3-(3,3,3-trifluoropropyl)naphthalene

Ausbeute 80.0%

Lösungsmittel

THF

Reaktionsbedingungen

Vorschrift

2-Bromo-6-(methyloxy)-3-(3,3,3-trifluoropropyl)-1-naphthalenol (122) (0.47 g, 1.35 mmol) was treated with chloromethyl methyl ether in the presence of diisopropylethylamine in THF to give 0.42 g (80%) of the title compound (123) as a colorless oil. 1H NMR (400 MHz, CDCl3): δ 2.40-2.55 (m, 2H), 3.10-3.20 (m, 2H), 3.72 (s, 3H), 3.91 (s, 3H), 5.23 (s, 2H), 7.04 (d, J=2.6 Hz, 1H), 7.16 (dd, J1=9.3 Hz, J2=2.5 Hz, 1H), 7.43 (s, 1H), 8.03 (d, J=9.3 Hz, 1H).

Quelle