Reaktion #2079896

Reaktionsgleichung

(S)-tert-butyl 2-(4-benzylpiperazine-1-carbonyl)pyrrolidine-1-carboxylate

lithium aluminum hydride

→

desired product

Ausbeute 96.0%

(S)-1-benzyl-4-[(1-methylpyrrolidin-2-yl)methyl]piperazine

Ausbeute 96.0%

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was refluxed for 2 hours
2. 2
   Temperaturcooled
3. 3
   Sonstigequenched with water
4. 4
   Extraktionextracted with ethyl ether 2×50 ml
5. 5
   WaschenThe combined organic solution was washed with brine
6. 6
   Trocknendried over sodium sulfate
7. 7
   Einengenconcentrated

Vorschrift

(S)-tert-butyl 2-(4-benzylpiperazine-1-carbonyl)pyrrolidine-1-carboxylate 1.01 g (2.71 mmol) in THF (10 ml) was added slowly to a solution of 1M lithium aluminum hydride in THF (8.2 ml) at 0° C. under argon protection. The reaction mixture was refluxed for 2 hours, cooled, quenched with water and extracted with ethyl ether 2×50 ml. The combined organic solution was washed with brine, dried over sodium sulfate and concentrated to give 0.71 g of desired product in 96% yield.

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