Reaktion #2078

ord-929810e1bbe644d497f54844a1a40378

Reaktionsgleichung

C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
Dehydroepiandrosterone
c1ccncc1
pyridine
O
water
→
CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]32)C1
3β-acetoxy-5-androstene-17-one

Edukte

C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
Dehydroepiandrosterone
c1ccncc1
pyridine
O
water

Reagenzien

Keine

Lösungsmittel

—
anhydride acetic

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Filtrationcrystals are filtered
  2. 2
    Sonstigedried in vacuo

Vorschrift

Dehydroepiandrosterone (2.88 g, 10 mmol) is dissolved in a mixture (100 ml) of anhydride acetic and pyridine (1:1 v/v) and left at room temperature for 16 h. The mixture is then poured carefully into iced water and after 16 h, crystals are filtered and dried in vacuo.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728688uspto-grants-1998_03