Reaktion #2075744

Reaktionsgleichung

MeI

nitrophenol

C2

2-chloro-3-nitrophenol

cesium carbonate

→

2-chloro-3-nitroanisole

Ausbeute 98.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe DMF was evaporated in vacuo
2. 2
   Waschenwashed with water (150 mL), brine (4×100 mL)
3. 3
   Trocknendried over (MgSO4)
4. 4
   FiltrationThe organic phase was filtered
5. 5
   Sonstigeevaporated

Vorschrift

The nitrophenol starting material C2 (1.3 g; 7.49 mmol) was dissolved in DMF (10 mL) and to this solution was added ground cesium carbonate (2.92 g; 8.96 mmol), followed by MeI (1.4 mL; 22.5 mmol). The mixture was stirred at room temperature overnight. The DMF was evaporated in vacuo and the residue taken up in ether (150 mL), washed with water (150 mL), brine (4×100 mL), and then dried over (MgSO4). The organic phase was filtered and evaporated to afford the crude 2-chloro-3-nitroanisole C3 (98%; 1.38 g) as an orange solid.

Quelle