Reaktion #2075728

Reaktionsgleichung

4,6-Dichloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxy-pyrimidine

water

ammonia

→

title compound

Ausbeute 88.0%

6-Chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidin-4-ylamine

Ausbeute 88.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate thrice
2. 2
   WaschenThe combined organic phases were washed once with brine
3. 3
   Sonstigedried
4. 4
   Sonstigeevaporated

Vorschrift

4,6-Dichloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxy-pyrimidine (500 mg, 1.5 mmol) was suspended in ammonia saturated ethanol (10 mL) and heated in a CEM microwave at 125° C. for 30 min. The mixture was poured into 15 mL water and extracted with ethyl acetate thrice. The combined organic phases were washed once with brine, dried and evaporated to give the title compound (420 mg, 88% yield: 1H NMR (DMSO-d6) δ 7.59 (dd, 1H), 7.45 (br s, 2H), 7.39 (dd, 1H), 3.91 (s, 3H), 3.76 (s, 3H).

Quelle