Reaktion #2075697

Reaktionsgleichung

2,2,2-trifluoro-N-(2-methoxy-[1,3]dioxolan-4-ylmethyl)acetamide

octadecanol

pyridinium para-toluenesulfonate

→

2,2,2-trifluoro-N-(2-octadecyloxy-[1,3]dioxolan-4-ylmethyl)acetamide

Lösungsmittel

cyclohexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude reaction product
2. 2
   Waschenwashed with a saturated sodium hydrogen carbonate solution
3. 3
   Trocknenwith a saturated sodium chloride solution, dried over magnesium
4. 4
   Einengensulfate and then concentrated to dryness

Vorschrift

3 g of 2,2,2-trifluoro-N-(2-methoxy-[1,3]dioxolan-4-ylmethyl)acetamide (Ortho 1, 13.09 mmol) were mixed with 3.54 g of octadecanol (13.09 mmol). The mixture was melted at 80° C. and left for 2 hours after the addition of 32 mg of pyridinium para-toluenesulfonate (0.13 mmol). The crude reaction product was then dissolved in cyclohexane, washed with a saturated sodium hydrogen carbonate solution and then with a saturated sodium chloride solution, dried over magnesium. sulfate and then concentrated to dryness. This crude product was used as it was for the next step.

Quelle