Reaktion #2075692

Reaktionsgleichung

3,3′-iminobispropylamine

ethyl trifluoroacetate

→

2,2,2-trifluoro-N-{3-[3-(2,2,2-trifluoroacetylamino)propylamino]propyl}acetamide

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAt the end of the addition (3 hours later), the reaction mixture
2. 2
   Sonstigeto return to room temperature
3. 3
   Temperaturthe stirring was maintained for a few hours under argon

Vorschrift

35 g of 3,3′-iminobispropylamine (266.7 mmol) were solubilized in 150 ml of anhydrous tetrahydrofuran under an argon stream. The reaction mixture was then cooled to 0° C. on an ice bath and 65 ml of ethyl trifluoroacetate (546.8 mmol) were added dropwise (very slowly) using a dropping funnel. At the end of the addition (3 hours later), the reaction mixture was allowed to return to room temperature and the stirring was maintained for a few hours under argon.

Quelle