Reaktion #2075315

Reaktionsgleichung

product

1-[3-(4-Bromo-phenyl)-trans-cyclobutyl]-(2S)-2-methyl-pyrrolidine

NH3

→

title compound

4′-{3-[(2S)-2-Methyl-pyrrolidin-1-yl]-trans-cyclobutyl}-biphenyl-4-carbonitrile

Reaktionsbedingungen

Vorschrift

The title compound was prepared using the procedure described in Example 1C except substituting the product from Example 13A for the product from Example 1B. 1H NMR (300 MHz, CD3OD) δ 1.36 (d, J=6 Hz, 3 H), 1.72 (m, 1 H), 2.01 (m, 2 H), 2.24 (m, 1 H), 2.55 (m, 1 H), 2.63 (m, 1 H), 2.78 (m, 2 H), 3.02 (m, 1 H), 3.25 (m, 1 H), 3.42 (m, 1 H), 3.69 (m, 1 H), 3.90 (m, 1 H), 7.47 (d, J=9 Hz, 2 H), 7.68 (d, J=9 Hz, 2 H), 7.80 (AB q, 4 H); (DCl/NH3) m/z 317 (M+H)+.

Quelle