Reaktion #2075036

Reaktionsgleichung

pentafluorophenol

EDC

1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride

→

Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe contents of the flask are concentrated in vacuo
2. 2
   Sonstigedried under high vacuum
3. 3
   SonstigeThe resulting crude product is employed without further purification in the following stages

Vorschrift

358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.

Quelle