Reaktion #2070268

Reaktionsgleichung

5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide

quinoline-8-carboxylic acid

→

title compound

Ausbeute 49.0%

8-[5-(5-Methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazol-2-yl]-quinoline

Ausbeute 49.0%

Reaktionsbedingungen

Vorschrift

As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (200 mg, 0.92 mmol) was converted using quinoline-8-carboxylic acid instead of o-toluic acid to the title compound (SiO2, heptane:ethyl acetate=80:20 to 50:50, 160 mg, 49%) which was obtained as a white solid. MS: m/e=355.2 [M+H]+.

Quelle