Reaktion #2069929

Reaktionsgleichung

4-cyano-4′-hydroxybiphenyl

allyl bromide

potassium carbonate

2-butanone

→

4-allyloxy-4′-cyanobiphenyl

Ausbeute 91.3%

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA solution prepared
2. 2
   Temperaturwas refluxed for 7 hours
3. 3
   Waschenthe organic layer was washed with water
4. 4
   Trocknendried with anhydrous magnesium sulfate
5. 5
   SonstigeThe solvent was evaporated away
6. 6
   Sonstigethe resulting residue was purified through silica gel column chromatography
7. 7
   Sonstigefurther recrystallized from ethanol

Vorschrift

A solution prepared by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of allyl bromide and 25 g of potassium carbonate to 250 ml of 2-butanone was refluxed for 7 hours. Water was added to the reaction solution for liquid-liquid separation, and the organic layer was washed with water and dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the resulting residue was purified through silica gel column chromatography using toluene as an eluent solvent and then further recrystallized from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

Quelle