Reaktion #2066501

Reaktionsgleichung

1-[1-(2-toluoylmethyl)-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-benzyloxycarbonylphenyl)urea

→

(+)-3-[3-[1-(2-toluoylmethyl)-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]ureido]benzoic acid

Ausbeute 86.3%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtrated
2. 2
   Einengenthe filtrate was concentrated under reduced pressure

Vorschrift

10% Palladium carbon (200 mg) was added to a solution of 1-[1-(2-toluoylmethyl)-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-benzyloxycarbonylphenyl)urea (1.4 g) obtained from Step 3 in ethanol (50 ml), stirred for 8 hours at room temperature under hydrogen atmosphere. The reaction mixture was filtrated and the filtrate was concentrated under reduced pressure, to thereby obtain 1.04 g of (+)-3-[3-[1-(2-toluoylmethyl)-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]ureido]benzoic acid (Yield: 86%).

Quelle