Reaktion #2064

Reaktionsgleichung

NaOH

ethyl 3,3-bis(diethoxyphosphinyl)propionate

→

title compound

Ausbeute 96.0%

3,3-bis(diethoxylphosphinyl)-propanoic acid

Ausbeute 96.0%

Lösungsmittel

water

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Sonstigethe EtOH was evaporated
3. 3
   ExtraktionThe product was extracted into dichloromethane (5×50 ml)
4. 4
   TrocknenThe organic layer was dried (Na2SO4)
5. 5
   Einengenconcentrated

Vorschrift

A solution of NaOH (4.00 g, 100 mmol) in water (50 ml) was added to a solution of ethyl 3,3-bis(diethoxyphosphinyl)propionate (32.6 g, 87 mmol) in EtOH (100 ml), and heated at 80° C. for 1 hour. After cooling, the EtOH was evaporated, and the residue was acidified to methyl orange with 12N HCl. The product was extracted into dichloromethane (5×50 ml). The organic layer was dried (Na2SO4) and concentrated to give the title compound (28.8 g, 96%) as a viscous oil.

Quelle