Reaktion #2063062

Reaktionsgleichung

4-(3,4-dichlorophenyl)-1-piperazineethanamine

4-methyl-1-isothiocyanatobenzene

→

N-(4-methylphenyl)-N′-[2-[4-(3,4-dichlorophenyl)-1-piperazinyl]ethyl]thiourea

Ausbeute 99.2%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated
2. 2
   SonstigeThe residue was recrystallized from DIPE
3. 3
   FiltrationThe precipitate was filtered off
4. 4
   Sonstigedried
5. 5
   SonstigeThe product was used without further purification

Vorschrift

A mixture of 4-(3,4-dichlorophenyl)-1-piperazineethanamine (0.01 mol) and 4-methyl-1-isothiocyanatobenzene (0.01 mol) in tetrahydrofuran (300 ml) was stirred at room temperature for 1 hour. The solvent was evaporated. The residue was recrystallized from DIPE. The precipitate was filtered off and dried. The product was used without further purification, yielding 4.2 g N-(4-methylphenyl)-N′-[2-[4-(3,4-dichlorophenyl)-1-piperazinyl]ethyl]thiourea (interm. 6).

Quelle