Reaktion #2062385

Reaktionsgleichung

trichloroacetyl chloride

2-(p-chlorophenyl)pyrrole

potassium carbonate

→

title product

Ausbeute 77.7%

5-(p-Chlorophenyl)pyrrol-5-yl trichloromethyl ketone

Ausbeute 77.7%

Lösungsmittel

ethyl acetate

ether

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic phase is separated
2. 2
   Waschenwashed with brine
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   Einengenconcentrated in vacuo
5. 5
   Sonstigeto obtain a yellow solid
6. 6
   SonstigeThe solid is recrystallized from 2-propanol

Vorschrift

A solution of trichloroacetyl chloride (11.26 g, 0.0619 mol) in ether is treated with a solution of 2-(p-chlorophenyl)pyrrole (10.0 g, 0.0503 mol) in ether, stirred for four hours at room temperature, treated with saturated potassium carbonate solution and diluted with ethyl acetate. The organic phase is separated, washed with brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain a yellow solid. The solid is recrystallized from 2-propanol to give the title product as a yellow solid (12.63 g, mp 166°-168° C.) which is identified by 1HNMR spectral analysis.

Quelle