Reaktion #2062018

Reaktionsgleichung

benzyltrimethylammonium hydroxide

6-cyano-2,2-dimethyl-3,4-epoxychromane

2,4-dihydroxypyridine

water

→

expected product

Ausbeute 18.3%

trans-6-Cyano-4-(I,2-dihydro-4-hydroxy-2-oxopyrid-1-yl)-2,2-dimethylchroman-3-ol

Ausbeute 18.3%

Lösungsmittel

dioxane

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvents are evaporated off under vacuum
2. 2
   Sonstigethe residue is then crystallized by the addition of isopropyl ether
3. 3
   SonstigeThe crystals obtained
4. 4
   Filtrationfiltered off
5. 5
   Waschenwashed with acetone

Vorschrift

3 g of 6-cyano-2,2-dimethyl-3,4-epoxychromane are refluxed for 20 hours with 1.8 g of 2,4-dihydroxypyridine in 30 ml of dioxane and 20 ml of dimethylformamide, in the presence of 0.6 ml of a methanolic solution containing 35% of benzyltrimethylammonium hydroxide. The solvents are evaporated off under vacuum and the residue is then crystallized by the addition of isopropyl ether. The crystals obtained are taken up with water, filtered off and then washed with acetone to give 850 mg of the expected product.

Quelle