Reaktion #2061941

Reaktionsgleichung

water

diethyl ether

1-(2-(4-fluorophenylthio)-6-fluorophenyl)prop-2-en-1-ol

HBr

→

subtitle compound

1-[2-(4-fluorophenylthio)-6-fluorophenyl]3-bromoprop-1-ene

Lösungsmittel

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted twice with diethyl ether
2. 2
   WaschenThe extracts are washed with water
3. 3
   Trocknenbrine and dried over MgSO4

Vorschrift

1-(2-(4-fluorophenylthio)-6-fluorophenyl)prop-2-en-1-ol (2.29 g, 8.23 mmol) is dissolved in 10 ml of hexane and 10 ml of diethyl ether and cooled in an ice bath. Concentrated HBr acid (4.6 ml, 41.2 mmol) is then added dropwise and the reaction mixture is stirred vigorously for 5 hours at room temperature. The reaction mixture is then poured into water and extracted twice with diethyl ether. The extracts are washed with water and then brine and dried over MgSO4 to afford the subtitle compound.

Quelle