Reaktion #2061940

Reaktionsgleichung

NH4Cl

Vinylmagnesium bromide

2-(4-fluorophenylthio)-6-fluorobenzaldehyde

→

subtitle compound

1-[2-(4-fluorophenylthio)-6-fluorophenyl]prop-2-en-1-ol

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm to room temperature
2. 2
   Extraktionextracted twice with diethyl ether
3. 3
   WaschenThe extracts are washed with water
4. 4
   Trocknenbrine and dried over K2CO3

Vorschrift

2-(4-fluorophenylthio)-6-fluorobenzaldehyde (2.06 g, 8.23 mmol) is dissolved in 21 ml of dry THF and cooled to -78° C. Vinylmagnesium bromide solution (12.4 ml of a 1.0M solution in THF) is then added dropwise and the reaction mixture is allowed to warm to room temperature. The reaction mixture is then poured into saturated NH4Cl and extracted twice with diethyl ether. The extracts are washed with water and then brine and dried over K2CO3 to afford the subtitle compound.

Quelle