Reaktion #2060

Reaktionsgleichung

5,6,7,8-tetrahydro-2-[2,4-dichloro-5-(2-propynyloxy)phenyl]-6-hydroxy-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one

diethylaminosulfur trifluoride

→

title product

Ausbeute 37.7%

5,6,7,8 tetrahydro-2-[2,4-dichloro-5-(2-propynyloxy)phenyl]-6-fluoro-1,2,4-triazolo[4,3-α]pyridin-3(2H)-one

Ausbeute 37.7%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was then quenched with ice
2. 2
   Extraktionextracted with dichloromethane
3. 3
   TrocknenThe organic extracts were dried (MgSO4)
4. 4
   Einengenconcentrated in vacuo
5. 5
   Sonstigeto give a pale red solid
6. 6
   SonstigeThe crude product was purified by flash chromatography over silica gel
7. 7
   Wascheneluting with a 95:5 v
8. 8
   workup.ADDITIONv mixture of dichloromethane and methanol

Vorschrift

To a solution of 169 mg (0.477 mmol) of 5,6,7,8-tetrahydro-2-[2,4-dichloro-5-(2-propynyloxy)phenyl]-6-hydroxy-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one in 5 mL of dichloromethane was added 76 μl (0.573 mmol) of diethylaminosulfur trifluoride (DAST) at 0° C. The reaction mixture was stirred at 0° C. for 1h. The mixture was then quenched with ice and extracted with dichloromethane. The organic extracts were dried (MgSO4), and then concentrated in vacuo to give a pale red solid. The crude product was purified by flash chromatography over silica gel, eluting with a 95:5 v:v mixture of dichloromethane and methanol to give 64 mg of the title product as a pale yellow foam. 19F NMR (CDCl3, 400 MHz) δ-188 ppm, 1H NMR (CDCl3, 400 MHz) δ 7.5 (s,1H), 7.1 (s,1H), 5.2 (m,1H), 4.8 (s,2H), 4.2-3.6 (m,2H), 3.2-3.0 (m,1H), 3.0-2.6 (m,1H), 2.5 (s,1H), 2.3-1.8 (m,2H).

Quelle