Reaktion #2053036

Reaktionsgleichung

6-bromo-2-chlorobenzo[d]thiazole

2-fluoroethanamine hydrochloride

→

6-bromo-N-(2-fluoroethyl)benzo[d]thiazol-2-amine

Ausbeute 54.5%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to rt
2. 2
   Einengenthe mixture was concentrated
3. 3
   Sonstigechromatographed (6% to 60% EtOAc in hexane)

Vorschrift

A mixture of 6-bromo-2-chlorobenzo[d]thiazole (248 mg, 1 mmol), 2-fluoroethanamine hydrochloride (200 mg, 2 mmol), and TEA (303 mg, 3 mmol) in 3 mL MeOH was heated at 120° C. in a microwave reactor for 20 min. After cooling to rt, the mixture was concentrated and chromatographed (6% to 60% EtOAc in hexane) to afford 6-bromo-N-(2-fluoroethyl)benzo[d]thiazol-2-amine as a white solid (150 mg, 54%). MS (ESI) m/z 276.9 (M+H+).

Quelle