Reaktion #2050151

ord-a899b961adb4457fbe6bae2b806d6256

Reaktionsgleichung

Cc1onc(-c2ccccn2)c1COc1ccc(C(=O)O)nc1
5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid
Cl.N[C@@H]1CCC[C@H]1O
trans-2-aminocyclopentanol hydrochloride
Cc1onc(-c2ccccn2)c1COc1ccc(C(=O)N[C@H]2CCC[C@@H]2O)nc1
title compound
Ausbeute 78.0%
Cc1onc(-c2ccccn2)c1COc1ccc(C(=O)N[C@H]2CCC[C@@H]2O)nc1
5-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid ((1S,2S)-2-hydroxy-cyclopentyl)-amide
Ausbeute 78.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

As described for example 7, 5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (100 mg, 0.32 mmol) was converted, using trans-2-aminocyclopentanol hydrochloride instead of isopropylamine, to the title compound (100 mg, 78%), which was obtained as a white solid. MS: m/e=395.1 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08415379B2uspto-grants-2013_04