Reaktion #2048818

Reaktionsgleichung

6-Benzyl-2-(4-fluoro-phenyl)-2-methoxy-1-oxa-6-aza-spiro[2.5]octane

HCl

water

→

title compound

Ausbeute 96.2%

(1-Benzyl-4-hydroxy-piperidin-4-yl)-(4-fluoro-phenyl)-methanone

Ausbeute 96.2%

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtrated
2. 2
   Sonstigethe solid was recrystallized ethanol/ether

Vorschrift

6-Benzyl-2-(4-fluoro-phenyl)-2-methoxy-1-oxa-6-aza-spiro[2.5]octane (0.600 g, 1.83 mmol) was solved in ether (6 mL), 0.6 mL of aqueous HCl was added (37%) and the reaction mixture was stirred at room temperature. After 0.5 h the reaction was finished and water was added and the product precipitate. The mixture was filtrated and the solid was recrystallized ethanol/ether to yield the title compound as a white solid (0.550 g, 1.76 mmol, 96%). MS (m/e): 314.0 (M+H+).

Quelle