Reaktion #2048532

Reaktionsgleichung

3-iodo-2-(iodomethyl)prop-1-ene

N,N-diisopropylethylamine

2-nitro-1-(2,5-difluorophenyl)ethanone

→

3-methylene-5-nitro-6-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated
2. 2
   Sonstigepurified by chromatography (silica gel, gradient 0-30% dichloromethane in hexane)

Vorschrift

N,N-diisopropylethylamine (184 mL) was added to a solution of 2-nitro-1-(2,5-difluorophenyl)ethanone (92.7 g, 461 mmol) in N,N-dimethylformamide (1000 mL) and 3-iodo-2-(iodomethyl)prop-1-ene (156 g, 507 mmol). The mixture was heated at 60° C. for 2 h, evaporated and purified by chromatography (silica gel, gradient 0-30% dichloromethane in hexane) to yield 3-methylene-5-nitro-6-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran.

Quelle