Reaktion #2046063

Reaktionsgleichung

water

1-(3,4-dichlorophenyl)-1H-pyrazol-3-amine

triethylamine

2-chloroacetyl chloride

→

2-chloro-N-(1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl)acetamide

Ausbeute 92.9%

Lösungsmittel

tetrahydrofurane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Sonstigethe organic solvent evaporated in vacuo
3. 3
   FiltrationThe resulting suspension was filtered
4. 4
   Sonstigedried

Vorschrift

To a solution, ice cooled, of 1-(3,4-dichlorophenyl)-1H-pyrazol-3-amine (0.36 g, 1.59 mmol) and triethylamine (0.24 g, 2.38 mmol) in dry tetrahydrofurane (5 ml), 2-chloroacetyl chloride (0.2 g, 1.79 mmol) was added. The mixture was stirred overnight at room temperature, water added and the organic solvent evaporated in vacuo. The resulting suspension was filtered and dried yielding 0.45 g of 2-chloro-N-(1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl)acetamide as a beige colour solid.

Quelle