Reaktion #2045382

ord-2757cdf63a0c4abe9f58f3ba5d6f8c72

Reaktionsgleichung

Nc1cnc(OC2CCC2)c(-c2ccc(Cl)cc2)c1
5-(4-chloro-phenyl)-6-cyclobutoxy-pyridin-3-ylamine
Cc1ocnc1C(=O)O
5-methyl-4-oxazolecarboxylic acid
→
Cc1ocnc1C(=O)Nc1cnc(OC2CCC2)c(-c2ccc(Cl)cc2)c1
title compound
Cc1ocnc1C(=O)Nc1cnc(OC2CCC2)c(-c2ccc(Cl)cc2)c1
5-Methyl-oxazole-4-carboxylic acid[5-(4-chloro-phenyl)-6-cyclobutoxy-pyridin-3-yl]-amide

Edukte

Nc1cnc(OC2CCC2)c(-c2ccc(Cl)cc2)c1
5-(4-chloro-phenyl)-6-cyclobutoxy-pyridin-3-ylamine
Cc1ocnc1C(=O)O
5-methyl-4-oxazolecarboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was synthesized in analogy to Example 42 g, using 5-(4-chloro-phenyl)-6-cyclobutoxy-pyridin-3-ylamine (example 78 d) and 5-methyl-4-oxazolecarboxylic acid (CAN 103879-58-9) as starting materials; LC-MS (UV peak area/ESI) 100%, 384.1102 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08410107B2uspto-grants-2013_04