Reaktion #2045104

Reaktionsgleichung

Benzamide

piperidine

Formaldehyde

→

Mannich base

N-Piperidin-1-ylmethyl-benzamide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe resulting solution was cooled in an ice bath
2. 2
   Temperaturit was refluxed for 4 h
3. 3
   TemperaturAfter cooling
4. 4
   Sonstigethe solvents were evaporated

Vorschrift

Benzamide (0.5 g, 0.4 mmol) was dissolved in 5 mL of methanol. To this stirred solution piperidine (0.35 mL, 0.4 mol) was added and the resulting solution was cooled in an ice bath. Formaldehyde (0.31 mL, 0.4 mol, 37% in water) was added dropwise. The solution was stirred for 10 min and then it was refluxed for 4 h. After cooling, the solvents were evaporated to give Mannich base 15 as a white solid 0.78 g (87% yield).

Quelle