Reaktion #2045092

Reaktionsgleichung

1-(4-chlorophenyl)ethanone

→

2-amino-1-(4-chlorophenyl)ethanone hydrochloride

2-bromo-1-(4-chlorophenyl)ethanone

Lösungsmittel

acetic acid

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter about 30 min. the mixture turned homogeneous
2. 2
   Filtrationwas filtered off
3. 3
   Waschenwashed with water (2×1 mL per mmol of starting ketone)
4. 4
   SonstigeDrying of the precipitate

Vorschrift

The starting 2-amino-1-(4-chlorophenyl)ethanone hydrochloride was prepared according to the following procedure. The 1-(4-chlorophenyl)ethanone (1.0 eq.) was dissolved in glacial acetic acid (1 mL per mmol). To this was added a slurry of pyridinium bromide perbromide (1.03 eq.) in acetic acid (1 mL per mmol). The heterogeneous mixture was stirred for 4 h at ambient temperature. After about 30 min. the mixture turned homogeneous. After pouring into ice-water a yellow precipitate was filtered off and washed with water (2×1 mL per mmol of starting ketone). Drying of the precipitate afforded 2-bromo-1-(4-chlorophenyl)ethanone in ca. 90% yield.

Quelle