Reaktion #2045039

Reaktionsgleichung

6-(4-nitrophenoxy) hexanoic acid methyl ester

6-(4-Nitro-phenoxy)-hexanoic acid methyl ester

→

53

Ausbeute 80.2%

6-(4-Nitrophenoxy)-hexanoic acid

Ausbeute 80.2%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 16 hours
2. 2
   Filtrationfiltered
3. 3
   Sonstigedried
4. 4
   Sonstigerecrystallised from a mixture of ethyl acetate:hexane (1:6)

Vorschrift

A mixture of 6-(4-nitrophenoxy) hexanoic acid methyl ester 39 (125 g, 468.16 mmol) and concentrated HCl (1250 ml) was refluxed for 16 hours. The reaction mixture was cooled to room temperature, filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 53 (95 g, 80.2%) as a white powder. M.p: 104-107° C.

Quelle