Reaktion #2045034

Reaktionsgleichung

2-(4-nitrophenoxy)propionic acid methyl ester

2-(4-Nitro-phenoxy)-propionic acid methyl ester

→

47

Ausbeute 85.3%

2-(4-Nitro-phenoxy)-propionic acid

Ausbeute 85.3%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 8 hours
2. 2
   FiltrationCrude 47 was filtered
3. 3
   Sonstigedried
4. 4
   Sonstigerecrystallised from a mixture of ethyl acetate:hexane (1:5)

Vorschrift

A mixture of 2-(4-nitrophenoxy)propionic acid methyl ester 35 (50 g) and concentrated HCl (500 ml) was refluxed for 8 hours. The reaction mass was cooled to room temp. Crude 47 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 47 (40 g, 85.3%) as a white powder. M.p: 139-141° C.

Quelle