Reaktion #2045003

Reaktionsgleichung

Paracetamol

K2CO3

ethyl bromoacetate

→

13

Ausbeute 80.1%

(4-Acetylamino-phenoxy)-acetic acid ethyl ester

Ausbeute 80.1%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 16 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (5 liter) was added
4. 4
   FiltrationCrude 13 was filtered
5. 5
   Sonstigedried
6. 6
   Sonstigerecrystallised from a mixture of toluene:hexane (1:5)

Vorschrift

To a mixture of Paracetamol (300 g, 1.984 mol), and anhydrous K2CO3 (1.80 Kg, 7.814 mmol) in anhydrous acetone (3 liters) was added ethyl bromoacetate (452 gr, 2.7 mol) and refluxed for 16 hours. Acetone was distilled off and water (5 liter) was added. Crude 13 was filtered, dried and recrystallised from a mixture of toluene:hexane (1:5) to give pure 13 (377 g, 80%) as a white shining powder. The melting point was found to be 104.2-106.2° C.

Quelle