Reaktion #2039999

ord-0011b2efe78c4817b34dda2a8a08983c

Reaktionsgleichung

Cl
Hydrochloric acid
CCCCCCCCCCCCCCCCCCN(C=O)c1ccccc1COC(=O)NCCCN(CCCC)CCCC
[2-[[N-[3-(dibutylamino)propyl]carbamoyloxy]methyl]phenyl]-N-octadecylformamide
→
CCCCCCCCCCCCCCCCCCN(C=O)c1ccccc1COC(=O)NCCCN(CCCC)CCCC.Cl
aimed compound
CCCCCCCCCCCCCCCCCCN(C=O)c1ccccc1COC(=O)NCCCN(CCCC)CCCC.Cl
[2-[[N-[3-(Dibutylamino)propyl]carbamoyloxy]methyl]phenyl]-N-octadecylformamide hydrochloride

Edukte

Cl
Hydrochloric acid
CCCCCCCCCCCCCCCCCCN(C=O)c1ccccc1COC(=O)NCCCN(CCCC)CCCC
[2-[[N-[3-(dibutylamino)propyl]carbamoyloxy]methyl]phenyl]-N-octadecylformamide

Reagenzien

Keine

Lösungsmittel

CCOC(C)=O
ethyl acetate
CCOC(C)=O
ethyl acetate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturwhile being cooled with ice
  2. 2
    Einengenthe reaction mixture was concentrated

Vorschrift

4N Hydrochloric acid--ethyl acetate solution (1.36 ml) was added to a solution of [2-[[N-[3-(dibutylamino)propyl]carbamoyloxy]methyl]phenyl]-N-octadecylformamide (2.60 g) in ethyl acetate (26 ml) while being cooled with ice. After being stirred for 30 minutes, the reaction mixture was concentrated, thereby yielding 2.75 g of the aimed compound as white solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06114325uspto-grants-2000_09