Reaktion #2039986

ord-4008010ea445409c9e17abe4b1e30ebf

Reaktionsgleichung

Cl
Hydrochloric acid
CCCCCCCCCCCCCCCCCCNC(=O)OCc1ccccc1N(C=O)CCCN(C)C
N-[3-(dimethylamino)propyl]-{2-[(N-octadecylcarbamoyloxy)methyl]phenyl}formamide
→
CCCCCCCCCCCCCCCCCCNC(=O)OCc1ccccc1N(C=O)CCCN(C)C.Cl
aimed compound
CCCCCCCCCCCCCCCCCCNC(=O)OCc1ccccc1N(C=O)CCCN(C)C.Cl
N-[3-(Dimethylamino)propyl]-{2-[(N-octadecylcarbamoyloxy)methyl]phenyl}formamide hydrochloride

Edukte

Cl
Hydrochloric acid
CCCCCCCCCCCCCCCCCCNC(=O)OCc1ccccc1N(C=O)CCCN(C)C
N-[3-(dimethylamino)propyl]-{2-[(N-octadecylcarbamoyloxy)methyl]phenyl}formamide

Reagenzien

Keine

Lösungsmittel

CCOC(C)=O
ethyl acetate
CCOC(C)=O
ethyl acetate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Einengenthe reaction mixture was concentrated
  2. 2
    SonstigeThe residue was recrystallized from ethyl acetate

Vorschrift

4N Hydrochloric acid--ethyl acetate solution (0.35 ml) was added to a solution of N-[3-(dimethylamino)propyl]-{2-[(N-octadecylcarbamoyloxy)methyl]phenyl}formamide (0.49 g) in ethyl acetate (10 ml) at room temperature. After being stirred for 5 minutes, the reaction mixture was concentrated. The residue was recrystallized from ethyl acetate, thereby yielding 0.41 g of the aimed compound as white crystals.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06114325uspto-grants-2000_09