Reaktion #2035666

Reaktionsgleichung

(S)-ethyl piperidine-3-carboxylate

4-(2-bromoacetyl)benzonitrile

→

(S)-ethyl 1-(2-(4-cyanophenyl)-2-oxoethyl)piperidine-3-carboxylate hydrobromide

Ausbeute 62.7%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe next day, the precipitated solid was collected by filtration
2. 2
   Waschenwashed with ethyl acetate (×3)
3. 3
   Sonstigedried under vacuum

Vorschrift

To a solution of commercially available (S)-ethyl piperidine-3-carboxylate (10 g, 63.6 mmol) in 200 mL toluene was added 4-(2-bromoacetyl)benzonitrile (17 g, 76 mmol). The reaction mixture was stirred overnight. The next day, the precipitated solid was collected by filtration and washed with ethyl acetate (×3) and dried under vacuum to give 15.2 g of (S)-ethyl 1-(2-(4-cyanophenyl)-2-oxoethyl)piperidine-3-carboxylate hydrobromide. MS (M+1)=301. HPLC Peak RT=1.51 minutes.

Quelle