Reaktion #2033192

ord-627e16e5914144bfbfaa5111362f764c

Reaktionsgleichung

c1ccc2[nH]c(C3CC3)nc2c1
2-cyclopropylbenzimidazole
CCOC(=O)C(C)(C)N1CCN(Cc2nc3c(N4CCOCC4)nc(Cl)nc3n2C)CC1
ethyl 2-(4-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate
CCOC(=O)C(C)(C)N1CCN(Cc2nc3c(N4CCOCC4)nc(-n4c(C5CC5)nc5ccccc54)nc3n2C)CC1
500
CCOC(=O)C(C)(C)N1CCN(Cc2nc3c(N4CCOCC4)nc(-n4c(C5CC5)nc5ccccc54)nc3n2C)CC1
ethyl 2-(4-((2-(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewere reacted

Vorschrift

Following General Procedure I for Buchwald coupling, 2-cyclopropylbenzimidazole and ethyl 2-(4-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate were reacted to give 500. LCMS m/z: 588.4 (MH+)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08394796B2uspto-grants-2013_03