Reaktion #2028892

Reaktionsgleichung

compound

4-[4-bromomethyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

collidine

dimethyl sulfoxide

→

desired product

Ausbeute 66.0%

4-[4-formyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Ausbeute 66.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction solution was partitioned between ethyl acetate and water
2. 2
   Waschenthe organic solution was washed with water
3. 3
   Sonstigedried
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe residue was chromatographed (1:1 hexane:ethyl acetate)

Vorschrift

To a solution of the compound prepared in Step 1 (362 mg, 0.79 mmol) in dimethyl sulfoxide (7 mL) was added collidine (0.14 mL, 1.0 mmol). The solution was heated at 120° C. for 3 hours and then kept at overnight at room temperature. The reaction solution was partitioned between ethyl acetate and water and the organic solution was washed with water, dried and concentrated. The residue was chromatographed (1:1 hexane:ethyl acetate) to give the desired product (205 mg, 66%).

Quelle