Reaktion #2028884

Reaktionsgleichung

HCl

sodium methoxide

Ethyl trifluoroacetate

6-methyltetralone

→

oil

Ausbeute 85.1%

6-methyl-2-(trifluoroacetyl)tetralone

Ausbeute 85.1%

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic layer was collected
2. 2
   Waschenwashed with brine
3. 3
   Trocknendried over MgSO4
4. 4
   Einengenconcentrated in vacuo

Vorschrift

Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 1N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.

Quelle