Reaktion #2025691

Reaktionsgleichung

hydrochloric acid

methyl 6-[5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoate

sodium hydroxide

→

title product

6-[5-Ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoic acid

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter this period
2. 2
   Einengenthe reaction mixture is concentrated in vacuo
3. 3
   Sonstigeto obtain a residue
4. 4
   TemperaturThe residue is cooled with an ice bath
5. 5
   SonstigeThe resulting precipitate is isolated by vacuum filtration
6. 6
   Waschenwashed with water

Vorschrift

A stirred solution of methyl 6-[5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoate (5.14 g, 12.35 mmol) in tetrahydrofuran is treated with 2N sodium hydroxide (15 mL). The resulting mixture is stirred at room temperature for 24 hours. After this period, the reaction mixture is concentrated in vacuo to obtain a residue. The residue is cooled with an ice bath and acidified with concentrated hydrochloric acid. The resulting precipitate is isolated by vacuum filtration and washed with water to give the title product as a white solid, mp 76°-81° C.

Quelle