Reaktion #2020

Reaktionsgleichung

(R)-α-[N-(9-Fluorenylmethoxycarbonyl)amino]-benzenebutanoic acid

4-[N-methylamino]-2'-cyano-1,1'-biphenyl

oxalyl chloride

Triethylamine

→

(R)-α-[Amino]-N-methyl-N-[(2'-cyano)-[1,1'-biphenyl]-4-yl]benzenebutanamide

Lösungsmittel

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas obtained
2. 2
   Sonstigeused without further purification
3. 3
   workup.STIRRINGthe reaction mixture stirred for a further 6 h
4. 4
   SonstigeThe reaction was quenched with 4-(aminomethyl)-piperidine (0.5 ml)
5. 5
   workup.STIRRINGstirred for 15 minutes
6. 6
   Sonstigepartitioned between water and methylene chloride
7. 7
   SonstigeThe organic phase was separated
8. 8
   Sonstigedried
9. 9
   SonstigeThe volatiles were removed under reduced pressure
10. 10
    Sonstigethe residues chromatographed on silica gel

Vorschrift

(R)-α-[N-(9-Fluorenylmethoxycarbonyl)amino]-benzenebutanoic acid (500 mg; 1.25 mmol), was converted into its corresponding acid chloride according to the procedure descibed in Example 33, Step F using 1 drop of DMF, oxalyl chloride (136 μl) in methylene chloride (2.5 ml). A yellow solid which was the acid chloride (525 mg) was obtained and used without further purification. A portion of the acid chloride (222.8 mg; 0.528 mmol) was added to 4-[N-methylamino]-2'-cyano-1,1'-biphenyl (110 mg; 0.528 mmol) were dissolved in methylene chloride (1 ml) and stirred together for 2 h at room temperature. Triethylamine (73.6 μl; 0.528 mmol) was added and the reaction mixture stirred for a further 6 h. The reaction was quenched with 4-(aminomethyl)-piperidine (0.5 ml) and stirred for 15 minutes and then partitioned between water and methylene chloride. The organic phase was separated, dried over powdered potassium carbonate. The volatiles were removed under reduced pressure and the residues chromatographed on silica gel using ethyl acetate and then ethyl acetate and methanol 9:1 v/v. The yield of the desired product was 60.2 mg (30.8%). FAB-MS:- calculated for C24H23N30 369.2 found 370.0 (M+1).

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