Reaktion #2018592

Reaktionsgleichung

sodium hydride

4-(4-fluoro-phenyl)-thiazol-2-ol

bromoacetic acid tert-butyl ester

→

mixture

Ausbeute 96.2%

[4-(4-Fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester

Ausbeute 96.2%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe reaction mixture was stirred at room temperature for 2 h
2. 2
   SonstigeAfter evaporation, water
3. 3
   workup.ADDITIONwas added
4. 4
   Extraktionthe mixture was extracted with ethyl acetate
5. 5
   SonstigeThe combined organic phases were dried
6. 6
   Sonstigeevaporated

Vorschrift

123 mg (2.82 mmol) of sodium hydride (55% in mineral oil) were added to 500 mg (2.56 mmol) of 4-(4-fluoro-phenyl)-thiazol-2-ol in 15 ml of DMF. After stirring at room temperature for 30 min, 549.6 mg (2.82 mmol) of bromoacetic acid tert-butyl ester were added, and the reaction mixture was stirred at room temperature for 2 h. After evaporation, water was added, and the mixture was extracted with ethyl acetate. The combined organic phases were dried and evaporated to give 762 mg of a mixture of title compound and N-alkylated product.

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