Reaktion #2012360

Reaktionsgleichung

6-chloro-3-fluoro-2-methylpyridine

hydrazine hydrate

hydrazine hydrate

→

3-fluoro-6-hydrazinyl-2-methylpyridine

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter the mixture was refluxed for 5 hrs
2. 2
   Temperaturthe reaction was refluxed for 3 days
3. 3
   EinengenThe mixture was then concentrated to dryness
4. 4
   Sonstigestored under high vacuum overnight
5. 5
   SonstigeThis material was used without further purification

Vorschrift

To a mixture of 6-chloro-3-fluoro-2-methylpyridine (4.7 g, 32.3 mmol) in isopropanol (100 mL) was added hydrazine hydrate (5 g, 100 mmol). After the mixture was refluxed for 5 hrs, additional hydrazine hydrate (5 g, 100 mmol) was added, and the reaction was refluxed for 3 days. The mixture was then concentrated to dryness and stored under high vacuum overnight. This material was used without further purification.

Quelle