Reaktion #2010248

ord-7ec28c21dce247bf9d59c59c2919b149

Reaktionsgleichung

Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1
9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purine-8-carbaldehyde
Cc1csc(CCN)n1
2-(4-methylthiazol-2-yl)ethanamine
→
Cc1csc(CCNCc2nc3c(N4CCOCC4)nc(-n4c(C)nc5ccccc54)nc3n2C)n1
321
Cc1csc(CCNCc2nc3c(N4CCOCC4)nc(-n4c(C)nc5ccccc54)nc3n2C)n1
N-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-2-(4-methylthiazol-2-yl)ethanamine

Edukte

Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1
9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purine-8-carbaldehyde
Cc1csc(CCN)n1
2-(4-methylthiazol-2-yl)ethanamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewere reacted

Vorschrift

Following General Procedure L for reductive amination, 9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purine-8-carbaldehyde and 2-(4-methylthiazol-2-yl)ethanamine were reacted to give 321. [M+H]+ 504.6.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08173650B2uspto-grants-2012_05