Reaktion #2010020

Reaktionsgleichung

2-chloro-6-morpholin-4-yl-9-(tetrahydropyran-2-yl)-9H-purine-8-carbaldehyde

4-azetidin-3-ylpiperazin-2-one

sodium triacetoxyborohydride

→

title compound

Ausbeute 67.5%

4-{1-[2-Chloro-6-morpholin-4-yl-9-(tetrahydropyran-2-yl)-9H-purin-8-ylmethyl]azetidin-3-yl}piperazin-2-one

Ausbeute 67.5%

Lösungsmittel

DCE

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGto stir for 64 h
2. 2
   Filtrationthen filtered through Celite® which
3. 3
   Waschenwas washed with DCM
4. 4
   EinengenThe filtrate was concentrated in vacuo
5. 5
   workup.DISSOLUTIONthe resulting residue dissolved in EtOAc
6. 6
   Waschenwashed with NaHCO3, H2O and brine
7. 7
   TrocknenThe organic phase was dried (Na2SO4)
8. 8
   Einengenconcentrated in vacuo

Vorschrift

A mixture of 2-chloro-6-morpholin-4-yl-9-(tetrahydropyran-2-yl)-9H-purine-8-carbaldehyde (1.06 g, 3.01 mmol) and 4-azetidin-3-ylpiperazin-2-one (560 mg, 3.61 mmol) in DCE (60 mL) and DMF (20 mL) was allowed to stir at r.t. for 10 min before the addition of 4 Å powdered molecular sieves (3.0 g) followed by sodium triacetoxyborohydride (1.28 g, 6.04 mmol). The resulting mixture was allowed to stir for 64 h then filtered through Celite® which was washed with DCM. The filtrate was concentrated in vacuo and the resulting residue dissolved in EtOAc and washed with NaHCO3, H2O and brine. The organic phase was dried (Na2SO4) and concentrated in vacuo affording the title compound as a yellow gum (997 mg, 67%). LCMS (method A): RT 2.19 and 2.11 min [M−C5H9O+H]+ 407.3

Quelle