Reaktion #2008598

Reaktionsgleichung

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

4-(piperidin-1-yl)piperidine

→

title compound

Ausbeute 93.0%

3-Ethyl-6-methyl-5-{5-[(4-piperidin-1-yl)piperidine-1-sulfonyl]thiophen-2-yl}-1H-pyridin-2-one hydrochloride

Ausbeute 93.0%

Reaktionsbedingungen

Vorschrift

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 4-(piperidin-1-yl)piperidine as described in Steps 5 and 6, Example 24 to give the title compound as a white solid (93% yield). LC/MS: RT 2.17 min; m/e 450; 1H NMR (δ, ppm): 11.89 (1H, br), 10.44 (1H, br), 7.64 (1H, d), 7.37 (1H, s), 7.29 (1H, d), 3.78 (2H, d), 3.50 (2H, d), 2.78-2.98 (2H, m), 2.35-2.58 (2H, q), 2.34 (3H, s), 2.20 (2H, d), 1.60-1.96 (8H, m), 1.20-1.50 (2H, m), 1.10 (3H, t).

Quelle