Reaktion #2008597

Reaktionsgleichung

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

4-(pyrrolidin-1-yl)piperidine

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title compound

Ausbeute 58.0%

3-Ethyl-6-methyl-5-{5-[(4-pyrrolidin-1-yl)piperidine-1-sulfonyl]thiophen-2-yl}-1H-pyridin-2-one hydrochloride

Ausbeute 58.0%

Reaktionsbedingungen

Vorschrift

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 4-(pyrrolidin-1-yl)piperidine as described in Steps 5 and 6, Example 24 to give the title compound as a yellow solid (58% yield). LC/MS: RT 2.12 min; m/e 436; 1H NMR (δ, ppm): 11.89 (1H, br), 10.87 (1H, br), 7.64 (1H, d), 7.36 (1H, s), 7.29 (1H, d), 3.75 (2H, d), 3.46 (2H, m), 3.08-3.28 (2H, s), 2.87-3.08 (2H, s), 2.35-2.60 (2H, q), 2.35 (3H, s), 2.08-2.24 (2H, m), 1.69-2.03 (6H, m), 1.10 (3H, t).

Quelle