Reaktion #2008565

Reaktionsgleichung

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

1-(4-fluorophenyl)piperazine

→

title compound

Ausbeute 99.0%

3-Ethyl-5-{5-[4-(4-fluorophenyl)piperazine-1-sulfonyl]thiophen-2-yl}-6-methyl-1H-pyridin-2-one

Ausbeute 99.0%

Reaktionsbedingungen

Vorschrift

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 1-(4-fluorophenyl)piperazine as described in Step 5, Example 24 to give the title compound as a solid (99% yield). LC/MS: RT 3.92 min; m/e 462 (M+H); 1H NMR (δ, ppm): 11.84 (1H, s), 7.65 (1H, d); 7.38 (1H, s); 7.30 (1H, d), 6.94 (4H, m), 3.12 (8H, m), 2.39 (2H, q), 2.33 (3H, s), 1.07 (3H, t); 19F NMR −123.8.

Quelle